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Article

C-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain.

Human pathology - 1 Aug 2015

Abi-Raad Rita, Virk Renu K, Dinauer Catherine A, Prasad A, Morotti Raffaella A, Breuer Christopher K, Sosa Julie A, Udelsman Robert, Rivkees Scott A, Prasad Manju L

Abstract excerpt

Germline mutations in RET proto-oncogene associated with multiple endocrine neoplasia type 2 (MEN2) may affect codons for the extracellular cysteine-rich (ECR) or the intracellular tyrosine kinase (ITK) domain of the transmembrane receptor tyrosine kinase protein. We compared C-cell pathology in asymptomatic carriers of RET mutation affecting the 2 domains. Twenty-two asymptomatic carriers (median age, 9.5...

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Share to Carcinoma, Neuroendocrine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

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Share to Proto-Oncogene Proteins c-ret

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 26033033
DOI: 10.1016/j.humpath.2015.04.011

Genes

ITK
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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