Article
Genetic mapping of a susceptibility locus for disc herniation and spastic paraplegia on 6q23.3-q24.1.
Journal of medical genetics - 1 Jun 2002
Zortea M, Vettori A, Trevisan C P, Bellini S, Vazza G, Armani M, Simonati A, Mostacciuolo M L
Abstract excerpt
It has been suggested that a genetic factor(s) or a familial predisposition may contribute to the clinical manifestations of disc herniation; moreover, no genetic linkage between spinal disc herniation and spastic paraplegia has ever been described. A family with consanguineous parents and four of eight sibs affected by multiple disc herniations and spastic paraplegia was clinically and genetically analysed....
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