Article
Differential display of expressed genes in pancreatic cancer cells.
Biochemical and biophysical research communications - 26 Apr 2002
Gardner-Thorpe James, Ito Hiromichi, Ashley Stanley W, Whang Edward E
Abstract excerpt
Activating K-ras mutations occur in 80-95% of pancreatic cancers. The purpose of this study was to conduct an open, panoramic survey of gene expression, using K-ras status as the axis over which to sub-classify pancreatic cancers. Differential display was used to contrast mRNA purified from exponentially growing PANC-1 and Capan-2 cells (mutated K-ras) with Hs766T and BxPC-3 cells (wild-type). Differences were...
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