Article
Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 May 2002
Dionne I J, Garant M J, Nolan A A, Pollin T I, Lewis D G, Shuldiner A R, Poehlman E T
Abstract excerpt
INTRODUCTION: Genetic variants affecting adrenoceptors have been suggested to influence body fatness. A putative gain-of-function polymorphism in the beta(1)-adrenoceptor was recently discovered (Gly389Arg ADRB1). We examined the association between Gly389Arg ADRB1 and obesity status in a large cohort of well-characterized individuals. METHODS: First, a large cohort of 931 Caucasian women (55.0+/-12.2 y) were...
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