Article
Changes in glucose transport and water permeability resulting from the T310I pathogenic mutation in Glut1 are consistent with two transport channels per monomer.
The Journal of biological chemistry - 23 Aug 2002
Iserovich Pavel, Wang Dong, Ma Li, Yang Hong, Zuniga Felipe A, Pascual Juan M, Kuang Kunyan, De Vivo Darryl C, Fischbarg Jorge
Abstract excerpt
We studied glucose and water passage across wild type (WT) glucose transporter Glut1 and its T310I pathogenic mutant, expressing them in Xenopus laevis oocytes. We found that the T310I mutation produced a 8-fold decrease in glucose transport (zero-trans influx, 13 +/- 2% compared with WT), accompanied by a 2.8-fold increase in the osmotic water permeability (P(f) 280 +/- 40% compared with WT), and no change in...
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