Article
Quantitative molecular monitoring of residual tumor cells in chronic lymphocytic leukemia.
Annals of hematology - 1 May 2002
Pfitzner T, Reiser M, Barth S, Borchmann P, Schulz H, Schinköthe T, Oberhäuser F, Wessels J, Tur M, Diehl V, Engert A
Abstract excerpt
New therapeutic approaches for the treatment of B-cell chronic lymphocytic leukemia (B-CLL) can induce remarkable responses. Molecular remissions have been observed occasionally after high-dose chemotherapy. Thus, new improved techniques to monitor residual tumor cells on a molecular basis in CLL are warranted. For this purpose, a real-time quantitative allele-specific oligonucleotide polymerase chain reaction...
Topics
- Aged
- Alleles
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Antineoplastic Agents
- Computer Systems
- DNA, Neoplasm
- Female
- Humans
- Immunoglobulin Heavy Chains
- Leukemia, Lymphocytic, Chronic, B-Cell
- Male
- Middle Aged