Article
Transplantation of germ cells from glial cell line-derived neurotrophic factor-overexpressing mice to host testes depleted of endogenous spermatogenesis by fractionated irradiation.
Biology of reproduction - 1 Jun 2002
Creemers L B, Meng X, den Ouden K, van Pelt A M M, Izadyar F, Santoro M, Sariola H, de Rooij D G
Abstract excerpt
With a novel method of eliminating spermatogenesis in host animals, male germ cells isolated from mice with targeted overexpression of glial cell line-derived neurotrophic factor (GDNF) were transplanted to evaluate their ability to reproduce the phenotype previously found in the transgenic animals. Successful depletion of endogenous spermatogenesis was achieved using fractionated ionizing irradiation. A dose of...
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