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Human Papillomavirus E2 Down-regulates the Human Telomerase Reverse Transcriptase Promoter

1 Aug 2002

Abstract excerpt

The transcriptional regulation of the human telomerase reverse transcriptase (hTERT) gene is a critical step in transformation and differentiation. Human papillomavirus E2 protein inhibits cell growth in HPV-infected cells and triggers apoptosis in HeLa cells. Because E2 induces cell growth suppression and senescence, we hypothesize that the protein may modulate cellular gene expression related to these...

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Share to DNA Repair Mechanisms
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PMID: 12019268
DOI: 10.1074/jbc.m203706200

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