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Article

Spermiogenesis initiation in Caenorhabditis elegans involves a casein kinase 1 encoded by the spe-6 gene.

Genetics - 1 May 2002

Muhlrad Paul J, Ward Samuel

Abstract excerpt

Immature spermatids from Caenorhabditis elegans are stimulated by an external activation signal to reorganize their membranes and cytoskeleton to form crawling spermatozoa. This rapid maturation, termed spermiogenesis, occurs without any new gene expression. To better understand this signal transduction pathway, we isolated suppressors of a mutation in the spe-27 gene, which is part of the pathway. The...

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Identifiers

PMID: 12019230
DOI: 10.1093/genetics/161.1.143
PMCID: PMC1462088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Spermiogenesis initiation in Caenorhabditis elegans involves a casein kinase 1 encoded by the spe-6 gene.PMID 12019230Read ↗

spe-29 encodes a small predicted membrane protein required for the initiation of sperm activation in Caenorhabditis elegans.Semantic proximity Read ↗

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A New Player in the Spermiogenesis Pathway of Caenorhabditis elegans.Semantic proximity Read ↗

Subcellular patterns of SPE-6 localization reveal unexpected complexities in Caenorhabditis elegans sperm activation and sperm function.Semantic proximity Read ↗

Premature sperm activation and defective spermatogenesis caused by loss of spe-46 function in Caenorhabditis elegans.Semantic proximity Read ↗

The Caenorhabditis elegans spe-6 gene is required for major sperm protein assembly and shows second site non-complementation with an unlinked deficiency.Semantic proximity Read ↗

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SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans.Semantic proximity Read ↗

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The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin.Semantic proximity Read ↗

The Caenorhabditis elegans spe‐49 gene is required for fertilization and encodes a sperm‐specific transmembrane protein homologous to SPE‐42Semantic proximity Read ↗

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