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Article

Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling.

Developmental cell - 1 May 2002

Bruinsma Janelle J, Jirakulaporn Tanawat, Muslin Anthony J, Kornfeld Kerry

Abstract excerpt

C. elegans cdf-1 was identified in a genetic screen for regulators of Ras-mediated signaling. CDF-1 is a cation diffusion facilitator protein that is structurally and functionally similar to vertebrate ZnT-1. These proteins have an evolutionarily conserved function as positive regulators of the Ras pathway, and the Ras pathway has an evolutionarily conserved ability to respond to CDF proteins. CDF proteins...

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PMID: 12015965
DOI: 10.1016/s1534-5807(02)00151-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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