Article
Both baseline HIV-1 drug resistance and antiretroviral drug levels are associated with short-term virologic responses to salvage therapy.
AIDS (London, England) - 24 May 2002
Baxter John D, Merigan Thomas C, Wentworth Deborah N, Neaton James D, Hoover Marie L, Hoetelmans Richard M W, Piscitelli Stephen C, Verbiest Werner H A, Mayers Douglas L
Abstract excerpt
BACKGROUND: To determine the impact of HIV-1 drug resistance at baseline and antiretroviral drug levels (DL) during follow-up on virologic response to the next antiretroviral regimen. METHODS: Baseline genotypic and phenotypic susceptibility was obtained for plasma virus from patients failing a protease inhibitor-containing regimen. Untimed plasma antiretroviral DL were performed and the distribution of DL after...
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