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Article

Increased Risk of High‐Grade Anal Neoplasia Associated with a Human Papillomavirus Type 16 E6 Sequence Variant

1 May 2002

Abstract excerpt

Expression of the E6 and E7 genes of human papillomavirus (HPV) type 16 have been implicated in the etiology of anogenital premalignant and malignant lesions. To evaluate whether variations in the HPV-16 E6 sequence were related to the incidence of high-grade anal neoplasia, 628 HPV-16-positive anal specimens from 193 human immunodeficiency virus (HIV)-positive and 59 HIV-negative participants were typed for...

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PMID: 12001039
DOI: 10.1086/340125

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