Article
Human CCS gene: genomic organization and exclusion as a candidate for amyotrophic lateral sclerosis (ALS).
BMC genetics - 19 Apr 2002
Silahtaroglu Asli N, Brondum-Nielsen Karen, Gredal Ole, Werdelin Lene, Panas Marios, Petersen Michael B, Tommerup Niels, Tümer Zeynep
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive lethal disorder of large motor neurons of the spinal cord and brain. In approximately 20% of the familial and 2% of sporadic cases the disease is due to a defect in the gene encoding the cytosolic antioxidant enzyme Cu, Zn-superoxide dismutase (SOD1). The underlying molecular defect is known only in a very small portion of the remaining cases and...
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