Article
Polymorphisms in TNFA and TNFR2 affect outcome of unrelated bone marrow transplantation.
Bone marrow transplantation - 1 Apr 2002
Ishikawa Y, Kashiwase K, Akaza T, Morishima Y, Inoko H, Sasazuki T, Kodera Y, Juji T
Abstract excerpt
Effects of polymorphisms in TNFA and TNFR2 on the outcome of 462 cases of unrelated bone marrow transplantation (uBMT) were studied retrospectively. Four alleles of TNFA (U01-U04) distinguished by polymorphism in the upstream region, -1031 (T/C), -863 (C/A) and -857 (C/T), and two alleles of TNFR2 (196M/196R) distinguished by polymorphism at codon 196 were determined. Transplantation involving TNFA-U02- and/or...
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