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Article

RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta.

Nature - 18 Apr 2002

Takayanagi Hiroshi, Kim Sunhwa, Matsuo Koichi, Suzuki Hiroshi, Suzuki Tomohiko, Sato Kojiro, Yokochi Taeko, Oda Hiromi, Nakamura Kozo, Ida Nobutaka, Wagner Erwin F, Taniguchi Tadatsugu

Abstract excerpt

Osteoclasts are cells of monocyte/macrophage origin that erode bone matrix: regulation of their differentiation is central to the understanding of the pathogenesis and treatment of bone diseases such as osteoporosis. Signalling by RANKL (receptor activator of NF-kappaB ligand), also known as Tnfsf11, is essential for the induction of osteoclast differentiation, and it must be strictly regulated to maintain bone...

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Identifiers

PMID: 11961557
DOI: 10.1038/416744a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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