Article
Significant increase of colonic mutated crypts in ulcerative colitis correlatively with duration of illness.
Cancer research - 15 Apr 2002
Okayasu Isao, Hana Kiyomi, Yoshida Tsutomu, Mikami Tetuo, Kanno Jun, Fujiwara Mutsunori
Abstract excerpt
Mild periodic acid-Schiff (mPAS) staining can discriminate non-O-acetylated(mPAS positive) from O-acetylated (mPAS negative) epithelial sialoglycoproteins in human colonic mucosa, giving three haplotypes of expression of a single polymorphic autosomal gene (oat). Increase in mPAS-positive crypts in heterozygotes is an indication of mutations, and wholly mPAS-positive (stem cell mutated) crypts and clusters of two...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.