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Article

Transcriptional regulation of a contractile gene by mechanical forces applied through integrins in osteoblasts.

The Journal of biological chemistry - 21 Jun 2002

Wang Jiaxu, Su Ming, Fan Jennie, Seth Arun, McCulloch Christopher A

Abstract excerpt

We examined mechanotranscriptional regulation of the contractile gene, alpha-smooth muscle actin (SMA), in osteoblastic cells. Tensile forces were applied through collagen-coated magnetite beads to ROS17/2.8 cells. These cells were desmin-, vimentin+ and expressed low levels of SMA. After force application (480 piconewton/cell), SMA protein and mRNA were increased but beta-actin was unchanged. Beads coated with...

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Source

Identifiers

PMID: 11953441
DOI: 10.1074/jbc.M203130200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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