Article
Lessons to better understanding of hypoxia sensing. Acquired and congenital mutations resulting in polycythemia.
Advances in experimental medicine and biology - 1 Jan 2001
Prchal J T, Divoky V
Abstract excerpt
Adaptation of the organism to hypoxia has profound effect on multiple tissues including regulation of erythropoiesis, vasculogenesis, a proper regulation of embryogenesis as well as other functions. The elucidation of those congenital or acquired mutations giving rise to disease states affecting physiological systems devoted to oxygen homeostasis provides not only a practical diagnostic and potential therapeutic...
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