Cell Cluster Formation in Degenerate Lumbar Intervertebral Discs is Associated with Increased Disc Cell Proliferation

Abstract excerpt

Healthy human intervertebral discs contain relatively few cells and these are sparsely distributed. A characteristic feature of disc degeneration, however, is the appearance of cell clusters, particularly in damaged areas. How these clusters form is currently unknown. We have examined excised pathological human discs for evidence of cell proliferation. Disc sections were immunostained for the proliferating cell...

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