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Her-2/neu Gene Amplification in Low to Moderately Expressing Breast Cancers: Possible Role of Chromosome 17/Her-2/neu Polysomy

1 Sept 2001

Abstract excerpt

Overexpression of the Her-2/neu (HER2) oncogene is known to confer important prognostic and predictive value to patients with breast cancer. Controversy exists as to the best method for its determination caused primarily by the variable sensitivities of the different antibodies and interobserver differences, particularly in the group of breast cancers with borderline levels of expression of the protein product....

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PMID: 11906444
DOI: 10.1046/j.1524-4741.2001.21018.x

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