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Polysomy 17 in HER-2/neu Status Elaboration in Breast Cancer: Effect on Daily Practice

15 Jun 2005

Abstract excerpt

PURPOSE: To assess the effect of chromosome 17 copy number on HER-2/neu status determination in breast cancers. EXPERIMENTAL DESIGN: HER-2/neu gene copy and chromosome 17 centromere numbers were evaluated on 893 breast carcinomas using double color fluorescence in situ hybridization (FISH). The net and chromosome 17 corrected (ratio) HER-2/neu copy numbers were compared and related to immunohistochemistry done...

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PMID: 15958623
DOI: 10.1158/1078-0432.ccr-04-2256

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