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The Influence of Polysomy 17 on HER2 Gene and Protein Expression in Adenocarcinoma of the Breast

11 Aug 2005

Abstract excerpt

Breast carcinomas with amplification of HER2 on chromosome 17 are associated with HER2 protein overexpression, adversely affecting prognosis and predicting response to Herceptin therapy. Chromosome 17 polysomy is encountered in assessing HER2 gene status, and its impact on HER2 gene and protein expression remains unclear. This impact was investigated in breast carcinomas identified by fluorescence in situ...

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PMID: 16096413
DOI: 10.1097/01.pas.0000165528.78945.95

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The Influence of Polysomy 17 on HER2 Gene and Protein Expression in Adenocarcinoma of the BreastPMID 16096413Read ↗

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Absence of chromosome 17 polysomy in breast cancer: analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplificationSemantic proximity Read ↗

Her-2/neu overexpression due to polysomy 17 in breast cancer: molecular testing to guide therapeutic options.Semantic proximity Read ↗

HER2 Assessment by Immunohistochemical Analysis and Fluorescence In Situ HybridizationSemantic proximity Read ↗

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