Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid detection of the prion protein M129V polymorphism with the LightCycler.

Journal of neuroscience methods - 30 Mar 2002

Teupser Daniel, Heino Norman, Wilfert Wolfgang, Thiery Joachim

Abstract excerpt

The common single nucleotide polymorphism at codon 129 of the prion protein gene is a key determinant of the genetic susceptibility to Creutzfeldt-Jakob disease (CJD). Recently, a molecular classification of sporadic CJD based on the M129V genotype in conjunction with other determinants was proposed. In the present study, we describe the development and evaluation of a rapid fluorescent-based assay to detect this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Creutzfeldt-Jakob Syndrome
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Dyes

Share to Genetic Techniques

Share to Genetic Testing

Share to Photic Stimulation

Share to Polymerase Chain Reaction

Share to Prions

Source

Identifiers

PMID: 11897368
DOI: 10.1016/s0165-0270(02)00008-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid detection of the prion protein M129V polymorphism with the LightCycler.PMID 11897368Read ↗

Rapid typing of the codon 129 polymorphism of the human prion protein gene by combined real-time PCR and melting curve analysis.Semantic proximity Read ↗

Genetic Creutzfeldt-Jakob disease linked to the E200K mutation: a large cohort study.Semantic proximity Read ↗

Allelic discrimination of genetic human prion diseases by real-time PCR genotyping.Semantic proximity Read ↗

Distribution of the M129V polymorphism of the prion protein gene in a Turkish population suggests a high risk for Creutzfeldt-Jakob disease.Semantic proximity Read ↗

The First Meta-Analysis of the M129V Single-Nucleotide Polymorphism (SNP) of the Prion Protein Gene (PRNP) with Sporadic Creutzfeldt-Jakob Disease.Semantic proximity Read ↗

Genotyping of the prion protein gene at codon 129.Semantic proximity Read ↗

Creutzfeldt-Jakob disease risk and PRNP codon 129 polymorphism: necessity to revalue current data.Semantic proximity Read ↗

Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification.Semantic proximity Read ↗

Codon 129 polymorphism of the PRNP gene in normal Polish population and in Creutzfeldt-Jakob disease, and the search for new mutations in PRNP gene.Semantic proximity Read ↗

Genotype frequencies at codon 129 of the prion protein gene in Brazil: Implications in susceptibility to variant Creutzfeldt-Jakob disease compared to European and Asian populations.Semantic proximity Read ↗

LightCycler PCR assay for simultaneous detection of the H63D and S65C mutations in the HFE hemochromatosis gene based on opposite melting temperature shifts.Semantic proximity Read ↗

Rapid detection of prothrombotic mutations of prothrombin (G20210A), factor V (G1691A), and methylenetetrahydrofolate reductase (C677T) by real-time fluorescence PCR with the LightCycler.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.