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Article

Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant.

European journal of biochemistry - 1 Mar 2002

Lindberg Jimmy, Sigurdsson Snaevar, Löwgren Seved, Andersson Hans O, Sahlberg Christer, Noréen Rolf, Fridborg Kerstin, Zhang Hong, Unge Torsten

Abstract excerpt

The K103N substitution is a frequently observed HIV-1 RT mutation in patients who do not respond to combination-therapy. The drugs Efavirenz, MSC194 and PNU142721 belong to the recent generation of NNRTIs characterized by an improved resistance profile to the most common single point mutations within HIV-1 RT, including the K103N mutation. In the present study we present structural observations from Efavirenz in...

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Identifiers

PMID: 11895437
DOI: 10.1046/j.1432-1327.2002.02811.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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