Article
Neuropathological and behavioral consequences of adeno-associated viral vector-mediated continuous intrastriatal neurotrophin delivery in a focal ischemia model in rats.
Neurobiology of disease - 1 Mar 2002
Andsberg Gunnar, Kokaia Zaal, Klein Ronald L, Muzyczka Nicholas, Lindvall Olle, Mandel Ronald J
Abstract excerpt
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were continuously delivered to the striatum at biologically active levels via recombinant adeno-associated viral (rAAV) gene transfer 4-5 weeks prior to 30 min of middle cerebral artery occlusion (MCAO). The magnitude of the deficits in a battery of behavioral tests designed to assess striatal function was highly correlated to the extent of...
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