Article
The emerging power of chemical genetics.
Current opinion in cell biology - 1 Apr 2002
Specht Kimberly M, Shokat Kevan M
Abstract excerpt
Chemical genetic methods allow signal transduction pathways to be probed in a domain-specific manner. This subtle perturbation of function, when combined with classical genetic and biochemical data, allows for a better understanding of protein function. This in turn is leading to elucidation of pharmacological maps of signaling pathways. Recent studies have focused on diverse pathways, including the initiation of...
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