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Article

Male LH-independent sexual precocity in a 3.5-year-old boy caused by a somatic activating mutation of the LH receptor in a Leydig cell tumor.

The Journal of clinical endocrinology and metabolism - 1 Mar 2002

Richter-Unruh A, Wessels H T, Menken U, Bergmann M, Schmittmann-Ohters K, Schaper J, Tappeser S, Hauffa B P

Abstract excerpt

We describe the clinical features of severe sexual precocity in a 3.5-yr-old boy. Hormonal evaluation showed LH-independent T hypersecretion. Initial examination of the adrenals and testes revealed no evidence of congenital adrenal hyperplasia, hCG- or androgen-secreting tumors, or McCune-Albrigh...

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Source

Identifiers

PMID: 11889161
DOI: 10.1210/jcem.87.3.8294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11889161-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Male LH-independent sexual precocity in a 3.5-year-old boy caused by a somatic activating mutation of the LH receptor in a Leydig cell tumor.PMID 11889161Read ↗

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