Article
Venous sampling can be crucial in identifying the testicular origin of idiopathic male luteinising hormone-independent sexual precocity.
European journal of pediatrics - 1 Dec 2002
Richter-Unruh Annette, Jorch Norbert, Wessels Hendrika T, Weber Ernst A, Hauffa Berthold P
Abstract excerpt
UNLABELLED: It has been recently shown that male LH-independent sexual precocity is caused by a somatic activating mutation in the luteinising hormone receptor (LHR) of Leydig cell tumours. In each of the patients described to date, the tumour was a well-defined, single encapsulated nodule. We present a 5.7-year-old boy with nodular Leydig cell hyperplasia, who harbours a somatic mutation of the LHRgene. The boy...
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