Transcriptional regulation of the mouse steroid 5alpha-reductase type II gene by progesterone in brain

Abstract excerpt

The steroid 5alpha-reductase (5alpha-R) plays an important physiological role in the conversion of steroid hormones such as androgen and progesterone to their 5alpha-reduced derivatives. 5alpha-R type II (5alpha-R2), one of two 5alpha-R isoforms, is thought to be a key enzyme in the generation of neuroactive steroids in the brain, particularly allopregnanolone (AP), via the production of its precursor...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Estrogen and related hormone effects
• Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Share to Hormonal and reproductive studies