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Article

Functional Classification of ADAMs Based on a Conserved Motif for Binding to Integrin α9β1

1 May 2002

Abstract excerpt

ADAMs (a disintegrin and metalloproteases) are members of the metzincin superfamily of metalloproteases. Among integrins binding to disintegrin domains of ADAMs are alpha(9)beta(1) and alpha(v)beta(3), and they bind in an RGD-independent and an RGD-dependent manner, respectively. Human ADAM15 is the only ADAM with the RGD motif in the disintegrin domain. Thus, both integrin alpha(9)beta(1) and alpha(v)beta(3)...

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PMID: 11882657
DOI: 10.1074/jbc.m200086200

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