Article
The yeast glutaredoxins are active as glutathione peroxidases.
The Journal of biological chemistry - 10 May 2002
Collinson Emma J, Wheeler Glen L, Garrido Ester Ocón, Avery Angela M, Avery Simon V, Grant Chris M
Abstract excerpt
The yeast Saccharomyces cerevisiae contains two glutaredoxins, encoded by GRX1 and GRX2, which are active as glutathione-dependent oxidoreductases. Our studies show that changes in the levels of glutaredoxins affect the resistance of yeast cells to oxidative stress induced by hydroperoxides. Elevating the gene dosage of GRX1 or GRX2 increases resistance to hydroperoxides including hydrogen peroxide, tert-butyl...
Topics
- ATP-Binding Cassette Transporters
- Alcohols
- Benzene Derivatives
- Blotting, Western
- Chromatography, High Pressure Liquid
- Dose-Response Relationship, Drug
- Fungal Proteins
- Genotype
- Glutaredoxins
- Glutathione Peroxidase
- Glutathione Transferase
- Hydrogen Peroxide
- Oxidative Stress