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Article

Frequent microsatellite instability in lung cancer from chromate‐exposed workers

20 Feb 2002

Abstract excerpt

Although chromium has been the most extensively investigated metal with respect to mutagenicity and carcinogenicity, its genetic effects in humans are only partly understood. Our previous study demonstrated that lung cancer from chromate-exposed workers infrequently (20%) displayed p53 gene mutations as well as a particular mutation pattern. In the present study, we examined the replication error (RER) and loss...

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PMID: 11870883
DOI: 10.1002/mc.10035

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