Article
Isolation and expression of the human hPF20 gene orthologous to Chlamydomonas PF20: evaluation as a candidate for axonemal defects of respiratory cilia and sperm flagella.
American journal of respiratory cell and molecular biology - 1 Mar 2002
Pennarun Gaëlle, Bridoux Anne-Marie, Escudier Estelle, Dastot-Le Moal Florence, Cacheux Valère, Amselem Serge, Duriez Bénédicte
Abstract excerpt
Primary ciliary dyskinesia (PCD) is a heterogeneous congenital disorder characterized by bronchiectasis and chronic sinusitis, sometimes associated with situs inversus (i.e., Kartagener's syndrome) and male infertility. At the cell level, the disease phenotype includes various axonemal abnormalities of respiratory cilia and sperm flagella. We have previously isolated DNAI1, the first gene involved in these...
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