Article
Similar pattern of iNOS expression, NO production and cytokine response in genetic and vaccination-acquired resistance to Marek's disease.
Veterinary immunology and immunopathology - 1 Feb 2002
Djeraba Aouatef, Musset Eugène, Bernardet Nelly, Le Vern Yves, Quéré Pascale
Abstract excerpt
NO is produced by macrophages through activation of the inducible enzyme NOS and its production is triggered as an antiviral and antitumoral immune mechanism. Replication of Marek's disease herpes virus (MDV) is inhibited by NO in vitro. MDV induces T-lymphomas in the chicken and a genetic resistance to tumor development has been linked to the B21 major histocompatibility complex. During the first initial week of...
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