Article
Familial Down syndrome: evidence supporting cytoplasmic inheritance.
Clinical genetics - 1 Dec 2001
Arbuzova S, Cuckle H, Mueller R, Sehmi I
Abstract excerpt
The frequently observed familial aggregation of Down syndrome (DS) 47,+21 and other aneuploidies and the phenomenon of double aneuploidy involving DS cannot be accounted for by chance alone. To clarify possible aetiological factors, pedigrees from all 7 affected families with repeated marriages referred to two regional genetics centres were examined. In each case the recurrence of aneuploidy was on the mother's...
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