Article
Titin mutations as the molecular basis for dilated cardiomyopathy.
Biochemical and biophysical research communications - 22 Feb 2002
Itoh-Satoh Manatsu, Hayashi Takeharu, Nishi Hirofumi, Koga Yoshinori, Arimura Takuro, Koyanagi Takeshi, Takahashi Megumi, Hohda Shigeru, Ueda Kazuo, Nouchi Tatsuhito, Hiroe Michiaki, Marumo Fumiaki, Imaizumi Tsutomu, Yasunami Michio, Kimura Akinori
Abstract excerpt
Dilated cardiomyopathy (DCM) is a heterogeneous cardiac disease characterized by ventricular dilatation and systolic dysfunction. Recent genetic studies have revealed that mutations in genes for cardiac sarcomere components lead to DCM. The cardiac sarcomere consists of thick and thin filaments and a giant protein, titin. Because one of the loci of familial DCM was mapped to the region of the titin gene, we...
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