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Article

Molecular analysis of beta-thalassaemia patients in a high incidence area of southern Italy.

Clinical and laboratory haematology - 1 Dec 2001

Rigoli L, Meo A, Miceli M R, Alessio K, Caruso R A, La Rosa M A, Salpietro D C, Ricca M, Barberi I

Abstract excerpt

The prevalence of eight mutations in 84 patients with beta-thalassaemia major and in 16 subjects with thalassaemia intermedia was investigated. All of the patients were Italian, originating from Eastern Sicily (Messina area) and some Calabrian regions. Genomic DNA was amplified by polymerase chain reaction (PCR). DNA molecular investigations were performed by allele-specific oligonucleotide (ASO) hybridization,...

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PMID: 11843884
DOI: 10.1046/j.1365-2257.2001.00367.x

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