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Article

Mutations in aldosterone synthase gene of Milan hypertensive rats: phenotypic consequences.

American journal of physiology. Endocrinology and metabolism - 1 Mar 2002

Lloyd-MacGilp Susan A, Torielli Lucia, Bechtel Stephanie, Tripodi Grazia, Gomez-Sanchez Celso E, Zagato Laura, Bernhardt Rita, Kenyon Christopher J

Abstract excerpt

Using in vitro and in vivo methods, we have demonstrated increased sensitivity of adrenocortical steroidogenesis to ACTH in Milan hypertensive (MHS) compared with normotensive (MNS) rats and have investigated whether this is caused by mutations of steroidogenic enzymes. Genes encoding aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) in MHS and MNS have been cloned and sequenced. Nucleotide 752 (G)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11832364
DOI: 10.1152/ajpendo.00043.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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