Article
Origin of endothelial progenitors in human postnatal bone marrow.
The Journal of clinical investigation - 1 Feb 2002
Reyes Morayma, Dudek Arkadiusz, Jahagirdar Balkrishna, Koodie Lisa, Marker Paul H, Verfaillie Catherine M
Abstract excerpt
This study demonstrates that a CD34(-), vascular endothelial cadherin(-) (VE-cadherin(-)), AC133(+), and fetal liver kinase(+) (Flk1(+)) multipotent adult progenitor cell (MAPC) that copurifies with mesenchymal stem cells from postnatal human bone marrow (BM) is a progenitor for angioblasts. In vitro, MAPCs cultured with VEGF differentiate into CD34(+), VE-cadherin(+), Flk1(+) cells - a phenotype that would be...
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