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Article

Proteolytic processing of human zona pellucida proteins.

Biology of reproduction - 1 Feb 2002

Kiefer Susan McLeskey, Saling Patricia

Abstract excerpt

Formation of the egg's extracellular matrix, the zona pellucida, is critical for fertilization and development of growing embryos. Zona pellucida glycoproteins, ZP1, ZP2, and ZP3, are secreted to form an insoluble extracellular matrix surrounding mammalian eggs. All cloned mammalian zona pellucida sequences contain a furin consensus cleavage site, RX(K)/(R)R, upstream of a putative transmembrane domain, which...

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PMID: 11804956
DOI: 10.1095/biolreprod66.2.407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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