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Article

Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene.

The International journal of developmental biology - 1 Dec 2001

Odgren P R, Kim N, van Wesenbeeck L, MacKay C, Mason-Savas A, Safadi F F, Popoff S N, Lengner C, van-Hul W, Choi Y, Marks S C

Abstract excerpt

The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required for normal osteoclast differentiation. Although the genetic locus remains unknown, the phenotypic impact of the tl mutation on multiple systems has been well characterized. Some of its actions are similar to tumornecrosis factor superfamily member 11(TNFSF11; also called TRANCE, RANKL, ODF and OPGL) null...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11804028

Genes

TNFSF11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene.PMID 11804028Read ↗

The Role of RANKL (TRANCE/TNFSF11), a Tumor Necrosis Factor Family Member, in Skeletal Development: Effects of Gene Knockout and Transgenic RescueSemantic proximity Read ↗

Characterization of a spontaneous osteopetrosis model using RANKL-dysfunctional mice.Semantic proximity Read ↗

The osteopetrotic mutation toothless ( tl ) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossificationSemantic proximity Read ↗

Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat.Semantic proximity Read ↗

RANK-L and RANK: T Cells, Bone Loss, and Mammalian EvolutionSemantic proximity Read ↗

Osteopetrosis rescue upon RANKL administration to Rankl(-/-) mice: a new therapy for human RANKL-dependent ARO.Semantic proximity Read ↗

Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgeneSemantic proximity Read ↗

Insertion Mutation in Tnfrsf11a Causes a Paget's Disease-Like Phenotype in Heterozygous Mice and Osteopetrosis in Homozygous Mice.Semantic proximity Read ↗

A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNFSemantic proximity Read ↗

RANKL cytokine: from pioneer of the osteoimmunology era to cure for a rare disease.Semantic proximity Read ↗

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling BoneSemantic proximity Read ↗

RANK-dependent autosomal recessive osteopetrosis: characterization of five new cases with novel mutations.Semantic proximity Read ↗

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