Article
Evaluation of the ELOVL4 gene in patients with age-related macular degeneration.
Ophthalmic genetics - 1 Dec 2001
Ayyagari R, Zhang K, Hutchinson A, Yu Z, Swaroop A, Kakuk L E, Seddon J M, Bernstein P S, Lewis R A, Tammur J, Yang Z, Li Y, Zhang H, Yashar B M, Liu J, Petrukhin K, Sieving P A, Allikmets R
Abstract excerpt
Stargardt-like macular degeneration (STGD(3)) and autosomal dominant macular degeneration (adMD) share phenotypic characters with atrophic age-related macular degeneration (AMD). Mutations in a photoreceptor cell-specific factor involved in the elongation of very long chain fatty acids (ELOVL(4)) were shown to be associated with STGD(3), adMD, and pattern dystrophy. We screened 778 patients with AMD and 551...
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