Article
Preferential transmission of interleukin-1 receptor antagonist alleles in attention deficit hyperactivity disorder.
Molecular psychiatry - 1 Jan 2002
Segman R H, Meltzer A, Gross-Tsur V, Kosov A, Frisch A, Inbar E, Darvasi A, Levy S, Goltser T, Weizman A, Galili-Weisstub E
Abstract excerpt
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, where family data support substantial heritability.(1) To date, association studies focussed mainly on genes regulating dopaminergic neurotransmission.(2)Interleukin-1 (IL-1) activity in the brain has been implicated with differentiation of dopaminergic neurons(3,4) and modulation of central monoaminergic reactivity.(5) We...
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