Article
Increased Susceptibility of C1q-Deficient Mice toSalmonella entericaSerovar Typhimurium Infection
1 Feb 2002
Abstract excerpt
The role of the complement system in host defense against Salmonella infection is poorly defined. Bacterial cell wall O-antigen polysaccharide can activate the alternative pathway in vitro. No studies, however, have elucidated the role of the classical pathway in immunity to Salmonella spp. in vivo. C1q-deficient mice (C1qa(-/-)) on a 129/Sv genetic background and strain-matched controls were infected...
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