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Article

Leptin's sexual dimorphism results from genotype by sex interactions mediated by testosterone.

Obesity research - 1 Jan 2002

Martin Lisa J, Mahaney Michael C, Almasy Laura, MacCluer Jean W, Blangero John, Jaquish Cashell E, Comuzzie Anthony G

Abstract excerpt

OBJECTIVE: Recent studies have reported the existence of marked sexual dimorphism in serum leptin levels in humans, with women having approximately three times the levels of men. As we have shown for other measures of adiposity, such sexual dimorphism can arise from a special case of genotype by environment interaction, that of genotype by sex interaction. RESEARCH METHODS AND PROCEDURES: Using maximum...

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Source

Identifiers

PMID: 11786597
DOI: 10.1038/oby.2002.3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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