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Article

Rates of oxygen and hydrogen exchange as indicators of TPQ cofactor orientation in amine oxidases.

Biochemistry - 15 Jan 2002

Green Edward L, Nakamura Nobuhumi, Dooley David M, Klinman Judith P, Sanders-Loehr Joann

Abstract excerpt

This study presents the first detailed examination by resonance Raman (RR) spectroscopy of the rates of solvent exchange for the C5 and C3 positions of the TPQ cofactor in several wild-type copper-containing amine oxidases and mutants of the amine oxidase from Hansenula polymorpha (HPAO). On the basis of crystal structure analysis and differing rates of C5 [double bond] O and C3 [bond] H exchange within the...

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PMID: 11781110
DOI: 10.1021/bi011685y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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