[Genetic analysis results of patients with a retinoblastoma refractory to systemic chemotherapy].

doi:10.1016/j.oftal.2015.02.011

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Article

[Genetic analysis results of patients with a retinoblastoma refractory to systemic chemotherapy].

Archivos de la Sociedad Espanola de Oftalmologia - 1 Sept 2015

Ruiz del Río N, Abelairas Gómez J M, Alonso García de la Rosa F J, Peralta Calvo J M, de las Heras Martín A

Abstract excerpt

OBJECTIVE: To analyze the genetic alterations identified in the RB1 gene in retinoblastoma patients who do not respond to systemic chemotherapy. METHODS: A genetic analysis was performed on 115 patients with retinoblastoma, 40 of whom had received systemic chemotherapy, and 29 of them had bilateral disease. Descriptive and retrospective study. Non-responders were considered as patients who are finally enucleated....

Topics

Antineoplastic Combined Chemotherapy Protocols
DNA Mutational Analysis
Drug Resistance, Neoplasm
Eye Enucleation
Female
Genotype
Humans
Kaplan-Meier Estimate
Male
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Invasiveness

Neoplasms, Multiple Primary

Proportional Hazards Models

Retinal Neoplasms

Retinoblastoma

Retinoblastoma Binding Proteins

Retrospective Studies

Sequence Deletion

Source

Open in PubMed

Identifiers

PMID: 25817468
DOI: 10.1016/j.oftal.2015.02.011

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