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Article

Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegans.

Molecular and cellular biology - 1 Jan 2002

Nam Seunghee, Jin Yun-Hye, Li Qing-Lin, Lee Kwang-Youl, Jeong Goo-Bo, Ito Yoshiaki, Lee Junho, Bae Suk-Chul

Abstract excerpt

The Caenorhabditis elegans run gene encodes a Runt domain factor. Runx1, Runx2, and Runx3 are the three known mammalian homologs of run. Runx1, which plays an essential role in hematopoiesis, has been identified at the breakpoint of chromosome translocations that are responsible for human leukemia. Runx2 plays an essential role in osteogenesis, and inactivation of one allele of Runx2 is responsible for the human...

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Identifiers

PMID: 11756550
DOI: 10.1128/MCB.22.2.547-554.2002
PMCID: PMC139740

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