Article
Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegans.
Molecular and cellular biology - 1 Jan 2002
Nam Seunghee, Jin Yun-Hye, Li Qing-Lin, Lee Kwang-Youl, Jeong Goo-Bo, Ito Yoshiaki, Lee Junho, Bae Suk-Chul
Abstract excerpt
The Caenorhabditis elegans run gene encodes a Runt domain factor. Runx1, Runx2, and Runx3 are the three known mammalian homologs of run. Runx1, which plays an essential role in hematopoiesis, has been identified at the breakpoint of chromosome translocations that are responsible for human leukemia. Runx2 plays an essential role in osteogenesis, and inactivation of one allele of Runx2 is responsible for the human...
Topics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Core Binding Factor Alpha 1 Subunit
- Core Binding Factor Alpha 2 Subunit
- Core Binding Factor Alpha 3 Subunit
- Core Binding Factor alpha Subunits
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Gene Expression Regulation, Developmental