Article
Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes.
Diabetes - 1 Jan 2002
Stumvoll Michael, Tschritter Otto, Fritsche Andreas, Staiger Harald, Renn Walter, Weisser Melanie, Machicao Fausto, Häring Hans
Abstract excerpt
The adipocyte-derived hormone adiponectin seems to protect from insulin resistance, a key factor in the pathogenesis of type 2 diabetes. Genome-wide scans have mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome to chromosome 3q27, where the adiponectin gene is located. A common silent T-G exchange in nucleotide 94 (exon 2) of the adiponectin gene has been associated with increased...
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