Article
Contrast in the efficacy of hDAF mouse hearts between ex vivo perfusion and transplantation into primates.
Xenotransplantation - 1 Nov 2001
Verbakel C A, de Bruin R W, Bonthuis F, Jonker M, Dekker S, Marquet R L, IJzermans J N
Abstract excerpt
In recent experiments, in which we compared hDAF transgenic rat hearts perfused with 15% human serum in the Langendorff device and hDAF rat hearts transplanted into cynomolgus monkeys, we demonstrated that in the ex vivo heart perfusion model both homozygous and heterozygous hDAF hearts survived longer as nontransgenic controls. Surprisingly, we found that only homozygous hDAF hearts were protected against...
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